No Significant Risk Levels (nsrls) for the Proposition 65 Carcinogens 3,3'-dimethoxybenzidine and 3,3'-dimethoxybenzidine Dihydrochloride
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چکیده
The cancer potencies of 3,3'-dimethoxybenzidine dihydrochloride (commonly called odianisidine) and 3,3'-dimethoxybenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'dimethoxybenzidine dihydrochloride via drinking water (NTP, 1990). These sites were skin, Zymbal’s gland, preputial gland, small intestine, large intestine, liver, oral cavity, lung, and brain. For each of the tumor sites listed above, a probability distribution of cancer potency estimates was derived using likelihood theory. The linear term (q1) of the multistage model fit to dose response data for a given site represents the cancer potency for that site. The cancer potencies for the affected sites were summed probabilistically, according to their distributions, to obtain a combined distribution. This combined distribution representing cancer potency for all selected sites affected by 3,3'-dimethoxybenzidine dihydrochloride was derived through Monte Carlo analysis. The upper 95 percent confidence bound indicated by the combined distribution for these treatment-related tumor sites was taken as the cancer potency for 3,3'dimethoxybenzidine dihydrochloride.
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No Significant Risk Level (nsrls) for the Proposition 65 Carcinogens 3,3'-dimethylbenzidine and 3,3'-dimethylbenzidine Dihydrochloride
The cancer potencies of 3,3'-dimethylbenzidine (commonly called o-tolidine) and 3,3'dimethylbenzidine dihydrochloride were estimated from dose-response data for multiple treatment-responding tumor sites among male rats exposed orally to 3,3'-dimethylbenzidine dihydrochloride via drinking water (NTP, 1991). These sites included liver, lung, preputial gland, oral cavity, skin, small intestines, l...
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EXPEDITED CANCER POTENCY VALUES AND NO SIGNIFICANT RISK LEVELS (NSRLs) FOR SIX PROPOSITION 65 CARCINOGENS: CARBAZOLE, MeIQ, MeIQx, METHYL CARBAMATE, 4-N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1- BUTANONE, TRIMETHYL PHOSPHATE
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